The program was to integrate on the one side basic research, particularly genomics, transcriptomics, proteomics, high-throughput technologies, and synthetic chemistry to identify novel antigens and generate new vaccine formulations against enteropathogens, and on the other side the host response to enteropathogens and the development of cell-based and animal models to help rationalize R&D and prepare for transition to phase 1 trials.
The available training content and learning activities
- The content includes i/ the structure and function of the gut, ii/ the human microbiota, iii/ diarrheal diseases (epidemiology, pathogenesis, bacterial diarrhea and diagnosis), iv/ information about enteropathogens (Campylobacter, E coli, shigella, Vibrio cholera, rotavirus), and v/ content on vaccines for rotavirus & norovirus, cholera, ETEC, shigella, typhoid fever
- Leaning activities consist of annotated articles and case-based learning.
- The material and learning activities were developed for workshops including an Enteric vaccines workshop organized in Tel Aviv in 2013, a Clinical trials & Immunomonitoring workshop in Dhaka, Bangladesh in 2014, and a mucosal immunity and vaccines, in Hong Kong, in 2014.
- This material and these learning activities can now be utilized as learning and training tools for future academic courses and workshops.